ENGLISH |
中国科研实验室
| 第一作者： | Tang, J (Tang, Jie); Dong, WJ (Dong, Wenjin); Chen, FS (Chen, Fushan); Deng, L (Deng, Li); Xian, M (Xian, Mo); |
|---|---|
| 联系作者： | Tang, J (Tang, Jie); Dong, WJ (Dong, Wenjin); Chen, FS (Chen, Fushan); Deng, L (Deng, Li); Xian, M (Xian, Mo); |
| 发表年度： | 2021 |
| 页： | - |
| 摘要： | A strategy based on the cooperation between metal and bonded cofactor mimics was applied to the transfer hydrogenation of C=N bonds. We designed and synthesized a rhodium complex containing a 1,3-dimethylbenzoimidazole moiety, which could transfer hydride from a rhodium center to imine substrates in a biomimetic way. Under both transfer hydrogenation and reductive amination reaction conditions, the catalyst exhibited good selectivity towards C=N bonds. With the catalyst, 34 imines were transfer hydrogenated to corresponding amines and a key intermediate of retigabine was prepared via reductive amination in a greener way. According to the NMR observations and isotope experiments, a plausible mechanism for this biomimetic reduction of C=N bonds were proposed. |
| 刊物名称： | CATALYSIS SCIENCE & TECHNOLOGY |
| 影响因子： | 5.726 |
| 全文链接： | http://pubs.rsc.org/en/content/articlelanding/2021/CY/D1CY00904D |
